Fig. 3: Structural re-arrangements of IFN DDX58 locus.
From: Multiscale modelling of chromatin 4D organization in SARS-CoV-2 infected cells
a Mock HiC data of the genomic region (chr9:32300000-32700000, hg19) centered around the interferon response DDX58 gene. Below, CTCF signal is shown (data taken from ref. 4). b As (a), SARS-CoV-2 HiC and CTCF data. c Simulated contact map for Mock polymer model. Below, binding sites profile, probability of the anchor points and their orientation (Methods) is shown. d As panel c, SARS-CoV-2 model. e Example of 3D structure of DDX58 locus taken from an MD simulation of the Mock model. Different regions are differently colored according to the pattern of the contact maps. Pink and cyan spheres highlight the position of DDX58 and its enhancer respectively. f As (e), SARS-CoV-2 model. Source data are provided as a Source Data file.
