Fig. 6: Chromatin re-arrangements correlates with a combination of changes of CTCF and histone marks at DDX58 locus.
From: Multiscale modelling of chromatin 4D organization in SARS-CoV-2 infected cells
a Top panel: distribution of binding sites obtained from HiC data in Mock (left) and SARS-CoV-2 (right) conditions. Bottom panel: different epigenetic marks (data from ref. 4). In SARS-CoV-2 relevant reductions of RAD21 and H3K27ac are observed. b Cross-correlation analysis between binding site profiles and epigenetic marks. Significative correlations (Methods) at DDX58 locus in Mock (left) and SARS-CoV-2 (right) models are shown. Asterisks indicate strong changes of the correlation between Mock and SARS-CoV-2 infected conditions (Methods). Source data are provided as a Source Data file.
