Fig. 2: Establishment of meta and para C−H difluoromethylation of pyridines. | Nature Communications

Fig. 2: Establishment of meta and para C−H difluoromethylation of pyridines.

From: Introduction of the difluoromethyl group at the meta- or para-position of pyridines through regioselectivity switch

Fig. 2

a Choice of difluoromethylation reagent. b meta-functionalization. c para-functionalization. Yield of 5 was determined by 19F NMR using 1-bromo-4-fluorobenzene as the internal standard. E = CO2Me. EWG electron-withdrawing group, TMP 2,2,6,6-tetramethylpiperidine, CSA camphorsulfonic acid.

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