Fig. 7: FLI1-IDO1 level serves as an independent predictor of unfavorable prognosis in NPC.
From: FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity
A FLI1 and IDO1 protein expression was evaluated by IHC staining in 110 NPC tumor tissues. Scale bars, 200 μm (upper panel), 100 μm (lower panel). B IDO1 IHC scores in NPC tissues with high and low FLI1 expression (n = 110). The data are presented as the mean ± SD. Statistical analysis was performed by two-tailed Mann–Whitney test. C The association between FLI1 expression and survival status in NPC samples. Statistical analysis was conducted by two-sided χ2 test. D–G Kaplan–Meier analysis of overall (D) and locoregional recurrence-free (E) survival based on the FLI1-IDO1 expression level (n = 73). Statistical analysis was performed by log-rank test. Forest plots showing the significance of different prognostic variables in NPC overall (F) and locoregional recurrence-free (G) survival (n = 73). Statistical analysis was performed by multivariate Cox regression analyses. The data are presented as the mean ± SD. H The proposed working model of FLI1 in immune suppression and ICB resistance in NPC. Source data are provided as a Source Data file.
