Fig. 6: Pharmacokinetics and radiosensitization efficacy of aAGd-NWs in vivo.
From: Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination
a Schematic illustration of pharmacokinetic profiles. Created with BioRender.com. b Pharmacokinetic profiles of free ara-AMP and aAGd-NWs in vivo (n = 3 mice). c, d The dynamic concentrations of ara-AMP and Gd accumulated within tumor tissues determined by HPLC (c) and ICP-OES (d), respectively (n = 3 mice). Non-detectable (N.D.). e Normalized tumor growth curves of Vehicle, free ara-AMP, GGd-NCPs, and aAGd-NWs treatments with X-ray irradiation (5 Gy × 2 with fractions delivered 6 days apart), respectively (n = 8 mice). f Tumor weights after Vehicle, ara-AMP, GGd-NCPs, and aAGd-NWs treatments with irradiation, respectively (n = 8 mice). g–i Quantification of γ-H2Aχ (g), TUNEL (h) mean fluorescent intensity, and relative percentage of Ki67 positive cells (i) after different treatments (n = 3 mice). All data were shown as mean ± SD. Statistical significance was determined using two-tailed Student’s t-test for pairwise comparisons, and one-way ANOVA analysis of variance for multiple groups. p values > 0.05 were considered non-significant (N.S.), while p values < 0.05 were considered statistically significant. Source data are provided as a Source Data file.
