Fig. 6: Identification of causal 3′-UTR eQTLs and ilQTLs in ADAR.

A Plot showing the distribution of CDS and 3′-UTR eQTLs and ilQTLs for the ADAR gene. The y-axis represents the nominal eQTL p value for each variant. The exon where the 3′-UTR is found is colored orange. B A cohort of gastric cancer and melanoma patients was classified into responders (R, n = 80) vs non-responders (NR, n = 55) according to response efficacy with anti-PD-1 immunotherapy. Primary cancer RNAseq data from these patients were analyzed. Differential gene expression analysis revealed increased expression of ADAR in R compared to NR (two-sided Wilcoxon rank sum test, Benjamini Hochberg FDR correction). Boxplot lines represent the median and upper or lower quartiles, while upper whiskers represent the max and min. Gastric and Melanoma cancer types are colored with grey and red, respectively. C Correlation analysis between ADAR and TARDBP log2 TPM normalized expression performed using TIMER v2.0 (timer.cistrome.org). Data from 415 STAD patients are included and the Spearman’s correlation coefficient (rho) and p value are reported. A linear regression line is shown in blue; the gray shaded area represents the standard error of the regression. Figure data are provided in the Source Data file.