Fig. 7: ilQTL polygenic risk score for predicting response to immunotherapy in melanoma and gastric cancer patients.

A Comparison of the polygenic risk score (PRS) distribution in the non-responder (NR, n = 40) and responder (R, n = 27) groups of the testing population (two-sided, Wilcoxon rank sum test, Benjamini–Hochberg FDR correction). Boxplot lines represent the median and upper or lower quartiles, while upper whiskers represent the max and min. Gastric and Melanoma cancer types are colored with grey and red, respectively. B A receiver operator characteristic (ROC) curve showing the ability of the PRS score and PD-L1 expression classifications to distinguish between R and NR patients in the testing population. An Area Under the Curve (AUC) score is reported for both classifiers. Figure data are provided in the Source Data file.