Fig. 5: Impact of reference size on deconvolution accuracy of immune cell types using EPIC array data.
From: Benchmarking of methods for DNA methylome deconvolution
a Heatmap showing Spearman’s R2 values on 200 in silico mixtures for all deconvolution methods at variable numbers of marker loci. b Performance of deconvolution on 200 in silico mixtures using a 10 CpG reference. Algorithm-normalization combinations are visualized as circles, with size representing root mean squared error and color representing Spearman’s R2. Rows show deconvolution algorithms, columns show normalization methods. ‘X’ symbol represents missing values. Source data are provided as a Source Data file.
