Fig. 6: Impact of reference size on deconvolution accuracy for small proportions of immune cell types using EPIC array data. | Nature Communications

Fig. 6: Impact of reference size on deconvolution accuracy for small proportions of immune cell types using EPIC array data.

From: Benchmarking of methods for DNA methylome deconvolution

Fig. 6

a Line plot showing cubic smoothed splines of Spearman’s R2 values (y-axis) for in silico and in vitro datasets at increasing fraction sizes, ranging from 3 to 75% (x-axis, log-scaled). b Heatmap showing Spearman’s R2 values for small fractions (<30%) on 200 in silico mixtures for all deconvolution methods at variable numbers of marker loci. ‘X’ symbol represents missing values. Source data are provided as a Source Data file.

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