Fig. 8: Gene expression pattern analysis for the infarct region (IR) and border region (BR) of rats in different groups at 4 weeks after transplantation by RNA-Seq.
From: E-cardiac patch to sense and repair infarcted myocardium
A Principal component analysis (PCA) of the IR samples (left), the BR samples (middle) and all samples (right). B, C Differentially expressed genes (DEGs) in each pairwise comparison in the IR (B) and the BR (C). Upper: pyramid diagrams of the number of DEGs. Red represents the number of upregulated genes, blue represents the number of downregulated genes. Lower: the tables of the number of downregulated genes, upregulated genes and total DEGs. D Clustering trend analysis based on the union of differential genes comparing the groups (sham, Ecoflex, PDE and TRI-TENG) vs the MI group in the IR (left) and the BR (right). E Clustering trend analysis based on the union of differential genes comparing the groups (MI, Ecoflex, PDE and TRI-TENG) vs the sham group in the IR and the BR. F Clustering trend analysis based on the union of differential genes comparing TRI-TENG vs Ecoflex, TRI-TENG vs PDE and PDE vs Ecoflex in the IR and the BR. Left: Hierarchical clustering heatmap, right: gene expression trend diagram in the (D–F). G Gene expression heatmap of the specified function-related genes in different groups. Green, low expression. Red, high expression.
