Fig. 2: Spi1-knockdown increases microgliosis and astrogliosis in mouse model of Aβ amyloidosis. | Nature Communications

Fig. 2: Spi1-knockdown increases microgliosis and astrogliosis in mouse model of Aβ amyloidosis.

From: Effects of SPI1-mediated transcriptome remodeling on Alzheimer’s disease-related phenotypes in mouse models of Aβ amyloidosis

Fig. 2

a Representative images of IBA1-positive cells in brain slices from Spi1+/+;APP/PS1 and Spi1+/−;APP/PS1 mice. Scale bars, 500 μm. b Quantification of the IBA1-positive cell load in the cortical area. c Representative images of GFAP-positive cells in brain slices from Spi1+/+;APP/PS1 and Spi1+/−;APP/PS1 mice. Scale bars, 500 μm. d Quantification of the GFAP-positive area in the cortex. All values are mean ± SEM. *p < 0.05 and **p < 0.01 (unpaired, two-tailed t-test; WT, n = 13 (n = 8 males, n = 5 females) for Spi1+/+;APP/PS1; KD, n = 15 (n = 9 males, n = 6 females) for Spi1+/−;APP/PS1). Source data are provided as a Source data file.

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