Fig. 3: LV1 correlations between IdC MPM measures and NODDI in white matter. | Nature Communications

Fig. 3: LV1 correlations between IdC MPM measures and NODDI in white matter.

From: Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status

Fig. 3

a The relative contributions of each NODDI metric to the overall pattern are calculated as a sum of the design scores and expressed as a percentage. NDI is the primary driver of this pattern. b The strength and direction of the relationship that each measure of isodendritic core microstructure (R1, MTsat, R2*, PD) has with the voxels highlighted in (c) for each measure of white matter microstructure (NDI, ODI or FW). Error bars show 95% confidence intervals from 1000 bootstrapped samples. The midpoint of each bar represents the correlation using the full dataset. Non-significant correlations (confidence intervals overlapping with zero) are faded out. c The yellow color of the voxels indicates a positive relationship with the pattern shown in the top panel. Only voxels with a bootstrap ratio of >|2| are colored. Here, we see strong positive associations between R1 in all isodendritic core nuclei and NDI (as well as ODI) across most of the white matter. LC locus coeruleus, DR dorsal raphe, VTA ventral tegmental area, NbM nucleus basalis of Meynert, MTsat magnetization transfer saturation, PD proton density, NDI neurite density index, ODI orientation dispersion index, FW free water fraction. Source data are provided as a Source Data file.

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