Fig. 6: PLS results for APOE4 group analysis.

Pie charts (a) show the relative contributions of each NODDI metric to each LV, calculated as a sum of the design scores and expressed as a percentage. The bar charts (b) show the strength and direction of the correlation between each measure of isodendritic core microstructure (R1, MTsat, R2*, PD) with the voxels highlighted in panel c for each measure of white matter microstructure (NDI, ODI, FW). These data are shown separately for APOE4- (left b) and APOE4+ (right b) groups. The yellow voxels highlighted in c indicate a positive relationship with the pattern shown in panel b. The blue voxels indicate a negative relationship. Only voxels in c with a bootstrap ratio of >|2| are colored. Non-significant correlations in b are faded out. Error bars show 95% confidence intervals from 1000 bootstrapped samples. The midpoint of each bar represents the correlation using the full dataset. Here, we see the overall specificity of the first two patterns to the APOE4 positive group and the specificity of the third pattern to the APOE4 negative group. LC locus coeruleus, DR dorsal raphe, VTA ventral tegmental area, NbM nucleus basalis of Meynert, MTsat magnetization transfer saturation, PD proton density, NDI neurite density index, ODI orientation dispersion index, FW free water fraction, LV latent variable. Source data are provided as a Source Data file.