Fig. 1: Approaches for the synthesis bioisosteres of benzenes and stilbenes.

a Bioisosteres of benzenes; b representative natural stilbenes; c Ti-catalyzed [2σ + 2π] cycloaddition to obtain stilbene bioisosteres.
a Bioisosteres of benzenes; b representative natural stilbenes; c Ti-catalyzed [2σ + 2π] cycloaddition to obtain stilbene bioisosteres.