Fig. 1: Summary of the DEG analysis for active asthma in CAAPA. | Nature Communications

Fig. 1: Summary of the DEG analysis for active asthma in CAAPA.

From: Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations

Fig. 1

Panel A Volcano plot of DEG analysis for asthma in the full combined group (N = 253 cases, N = 283 controls) from all 7 sites. Color represents the number of sites where the uncorrected significance for the DEG analysis within the site was p-value < 0.05, and genes that did not cross FDR of 0.05 in full combined analysis are retained as black. Panel B Combined gene expression for top gene FN1 by site. Panel C Gene expression for top gene FN1 stratified by adult vs. pediatrics. Panel D DEG effect sizes (log2 fold change and the 95% confidence interval) for top gene FN1 looking at the full combined analysis, analysis stratified by adults vs. pediatrics and the analysis within each site. CAAPA sites are ordered based on average African ancestry (%YRI) from highest (Nigeria) to lowest (Brazil). The test used in the DEG analysis was a moderated two-sided t-statistic. Source data are provided as a Source Data file.

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