Fig. 7: Activation and Inhibition by opposite movement of the top of M4. | Nature Communications

Fig. 7: Activation and Inhibition by opposite movement of the top of M4.

From: Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

Fig. 7

Alignment of the TREK-2/Nb76 and TREK-2/Nb61 complexes with the TREK-2 Up-state show that activation by Nb76 is associated with outward movement of the top of M4 and the P2-M4 loop whilst inhibition by Nb61 involves movement in the opposite direction (red arrows). The location of the K2P modulator site behind the selectivity filter is indicated by the asterisk.

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