Fig. 4: Scope of Amides. | Nature Communications

Fig. 4: Scope of Amides.

From: Chiral dinitrogen ligand enabled asymmetric Pd/norbornene cooperative catalysis toward the assembly of C–N axially chiral scaffolds

Fig. 4

aReactions were carried out in 0.1 mmol scale with respect to amide 2. Conditions: 1 (1.5 equiv), 2a (0.10 mmol), Pd2(dba)3 (5 mol%), L25 (20 mol%), NBE (1.5 equiv), Ag2SO4 (2.0 equiv), H2O (200 μL), 4 ÅMS (100 mg) in toluene (0.05 M) at 80 °C for 36 h under N2. bDichloroethane instead of toluene was used as solvent. The ee’s were determined by chiral HPLC analysis.

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