Fig. 2: Hier_SSIM and evaluation across all callers (ICE-normalized Hi-C data at 10Kb resolution).

a Diagram of Hier_SSIM process. b Clustering of TAD hierarchy callers. Source data are provided as a Source Data file. c Hierarchical structures of representative region by callers. The green image in the first row represents the Hi-C heatmap. The remaining blue images show the distribution of TAD levels from each method. d Peak signals for structural protein CTCF around the boundary.