Fig. 6: Exploration for existence of TAD hierarchy. | Nature Communications

Fig. 6: Exploration for existence of TAD hierarchy.

From: A comprehensive benchmarking with interpretation and operational guidance for the hierarchy of topologically associating domains

Fig. 6

a Schematic diagram of three main hypotheses for the formation of TAD hierarchy. One is only the superposition of heterogeneous TADs from bulk data (the upper panel, pink), the second shows that exact TAD hierarchy exists in individual cell (the lower panel, blue), and the third supports the coexistence of the two (orange). Twisted light purple chromatin filaments form the TAD, highlighted by light blue circular shading. Various colored points or short curve located at convergence points indicate TAD boundaries (the left panel, pink and blue box). Hierarchical TAD pattern diagrams (the middle panel, pink and blue box). Actual hic heatmap (the right panel, pink and blue box). b Number of TAD boundaries at separate levels and various resolutions in mixed samples. Source data are provided as a Source Data file. c TAD hierarchy in 40.8-42.8 Mb on chr7 of all mixed samples.

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