Fig. 2: Antibodies exhibit strong cross-reactivity against HNVs.
Reactivity of representative antibodies of each group to the indicated NiVBD G (a), NiVMY G (b), HeV G (c), or NiVBD G head domain (d), as determined by ELISA (see also Supplementary Fig. 3a). Data are the mean ± s.d. of three replicates from one representative experiment. e Determination of the binding of antibodies to the natural structure of NiVBD G displayed on the 293T cell surface through flow cytometry (see also Supplementary Fig. 3b). Data are presented as the mean of triplicate measurements. Neutralizing curves of antibodies against pseudotyped rHIV-NiVMY (f), -NiVBD (g), -HeV (h), -NiVMY GV507I (i), -HeV GD582N (j), and -HeV-g2 (k), (see also Supplementary Fig. 5a). Data are presented as the mean ± s.d. of three replicates from one representative experiment. Neutralizing curves of antibodies against authentic NiVMY (l), NiVBD (m), or HeV (n). Representative data from one test are shown. o The neutralizing efficacy of representative G or F antibodies against HNVs (see also Supplementary Fig. 5b). Source data are provided as a Source Data file.
