Fig. 2: GSK treatment reshapes chromatin landscapes of CD8+ T cells. | Nature Communications

Fig. 2: GSK treatment reshapes chromatin landscapes of CD8+ T cells.

From: Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells

Fig. 2

a Heatmaps of ChIP-seq signals at LSD1-bound promoters (TSS ± 1 kb) in GSK- or Veh-treated CD8+ T cells, generated by K-means clustering on H3K4me2 signals. Heatmaps of ChIP-seq signals at defined enhancers (Peak ± 1 kb) with (b) or without (c) LSD1 binding, generated by K-means clustering on H3K4me1 signals. d Heatmaps of ChIP-seq signals at promoters (TSS ± 1 kb) of upregulated effector and cytokine genes and downregulated inhibitory receptor genes. IGV snapshots showing ChIP-seq tracks at genomic loci of Tnf (e), Slamf6 (f), and Pdcd1 (g). Differential peaks were determined by p < 0.05, with changes over 20% up/down. The presented data are from one of two repeated experiments (a–g).

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