Fig. 5: T2D early detection using our prediction model (Phenotype Definition IV; age, sex, family, and PRS).
From: AI-enhanced integration of genetic and medical imaging data for risk assessment of Type 2 diabetes
A Four subgroups (N = 550). B Survival rate (N = 550). C Median survival time (N = 550). P-values of G1 vs. G3, G2 vs. G3, and G4 vs. G3 were 0.092, 0.0014 (**), and 2.22 × 10–16 (***), respectively. D Follow-up time (N = 550). P-values of G1 vs. G3, G2 vs. G3, and G4 vs. G3 were 0.056, 0.32, and 0.14, respectively. E T2D risk (N = 550). P-values of G1 vs. G3, G2 vs. G3, and G4 vs. G3 were 0.018 (*), 0.073, and 0.0039 (**), respectively. F HbA1c (N = 550). P-values of G1 vs. G3, G2 vs. G3, and G4 vs. G3 were 2.21 × 10–14, 0.0039, and 3.00 × 10–5; respectively; in the follow-up, p-values of G1 vs. G3, G2 vs. G3, and G4 vs. G3 were 1.50 × 10-13, 6.01 × 10−4, and 4.55 × 10-6, respectively. G Fasting glucose (N = 550). In the baseline, p-values of G1 vs. G3, G2 vs. G3, and G4 vs. G3 were 2.06 × 10-12, 6.66 × 10–4, and 1.63 × 10–2; respectively; in the follow-up, p-values of G1 vs. G3, G2 vs. G3, and G4 vs. G3 were 8.30 × 10–8, 1.38 × 10–3, and 1.84 × 10–2, respectively. H Phenotype definition in G3 (N = 395). Many individuals in G3 cannot satisfy the T2D Phenotype Definition IV. In Fig. 5C–G, two-sided Wilcoxon rank-sum tests were applied to compare group differences. The box plots’ center lines indicate the medians, the lower and upper boundaries of the boxes represent the first and third quartiles, and the whiskers extend to cover a range of 1.5 interquartile distances from the edges. The violin plots’ upper and lower bounds depict the minimum and maximum values. Source data are provided as a Source Data file.
