Fig. 2: Identification of HNF4A-bound targets in beta cells and hepatic cells reveal enrichment for common and distinct pathways across tissue types and identified beta cell target genes. | Nature Communications

Fig. 2: Identification of HNF4A-bound targets in beta cells and hepatic cells reveal enrichment for common and distinct pathways across tissue types and identified beta cell target genes.

From: HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes

Fig. 2

a Top Gene Ontology (GO) Biological Processes (BP) commonly identified in both EndoC-βH1 and human islet HNF4A ChIP-Seq. b Top GO BP identified in D35 βLC HNF4A ChIP-Seq, in side-by-side comparisons with EndoC-βH1 and human islet samples. c Top GO BP in EndoC-βH1 in comparison with HepG2 HNF4A ChIP-Seq. d Venn diagram showing overlaps in HNF4A-bound target genes in EndoC-βH1 cells, human islets, and D35 βLCs based on ChIP-Seq peaks mapping within 10 kb of the transcription start site (TSS) (number of total peaks with no filtering shown in brackets). The table provides a list of the common beta-cell target gene loci identified, of which some were also replicated in D20 EPs (in green). Analysis and visualization of GO data is based on the ChIPseeker R package (see Methods).

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