Fig. 6: HNF4A and HNF1A commonly bind to several beta cell targets and govern overlapping pathways in both beta cells and hepatic cells. | Nature Communications

Fig. 6: HNF4A and HNF1A commonly bind to several beta cell targets and govern overlapping pathways in both beta cells and hepatic cells.

From: HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes

Fig. 6

a Topmost common and distinct gene ontology (GO) biological processes (BP) from HNF4A- and HNF1A-bound target genes in human islets. b Venn diagram showing overlap in HNF4A- and HNF1A-bound target genes in human islets based on ChIP-Seq peaks within 10 kb of the transcription start site (TSS) (number of total peaks with no filtering shown in brackets). Table provides a consensus list of the commonly-bound target genes. c Venn diagram showing overlaps in HNF4A- and HNF1A-bound target genes in HepG2 cells based on ChIP-Seq peaks within 10 kb of the transcription start site (TSS) (number of total peaks with no filtering shown in brackets). HNF4A-bound targets in HepG2 cells are from the consensus list of genes. d Topmost common and distinct gene ontology (GO) biological processes (BP) from HNF4A- and HNF1A-bound target genes in HepG2 cells. Analysis and visualization of GO data is based on the ChIPseeker R package (see Methods).

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