Fig. 7: PTBP1 promotes nuclear export of pre-miR-276 in Drosophila. | Nature Communications

Fig. 7: PTBP1 promotes nuclear export of pre-miR-276 in Drosophila.

From: Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Fig. 7

a Alignment of the pre-miR-276 sequence among insect species. Lmig: Locusta migratoria, Dmel: Drosophila melanogaster, Tcas: Tribolium castaneum, Ngri: Nasonia giraulti, Msex: Manduca sexta, Apis: Acyrthosiphon pisum, Bmor: Bombyx mori, Cqui: Culex quinquefasciatus. The asterisks indicate the conserved sequence among these insects. The 5p strand, 3p strand, and terminal loop of pre-miR-276 are emphasized by blue, green, and gray areas, respectively. The red boxes show the “CU motifs” in pre-miR-276. b Cytoplasmic/nuclear pre-miR-276 ratio in Drosophila S2 cells after Heph knockdown (n = 5 biologically independent cell samples, each cell sample was from one well of a 48-well plate). c miR-276/pre-miR-276 ratio after Heph knockdown in Drosophila S2 cells (n = 6 biologically independent cell samples, each cell sample was from one well of a 48-well plate). Student’s t test (two-tailed) was applied for two-group comparisons. The data are shown as the mean ± SEM. ** P < 0.01, *** P < 0.001. Source data and details of the statistical results are provided as a Source Data file.

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