Table 3 Baseline characteristics of hip fracture subphenotypes (UK THIN cohort)
UK THIN cohort | |||
|---|---|---|---|
Variables | Cluster 1 | Cluster 2 | SMD (p-valuea) |
n | 4966 | 22,982 | |
Males, n (%) | 1910 (38.5) | 5274 (22.9) | 0.341 (<0.001) |
Age, mean (SD) | 83.77 (6.85) | 82.20 (7.81) | 0.213 (<0.001) |
Diagnosis record within 5 years before index date, n (%) | |||
Coronary heart disease | 2147 (43.2) | 1090 (4.7) | 1.010 (<0.001) |
Congestive heart failure | 1502 (30.2) | 0 (0.0) | 0.931 (<0.001) |
Cerebrovascular diseases | 1322 (26.6) | 1525 (6.6) | 0.557 (<0.001) |
Hypertensive diseases | 997 (20.1) | 2658 (11.6) | 0.235 (<0.001) |
Arrhythmia and conduction disorders | 2263 (45.6) | 1108 (4.8) | 1.063 (<0.001) |
Arterial disease | 827 (16.7) | 600 (2.6) | 0.490 (<0.001) |
Chronic obstructive pulmonary disease | 965 (19.4) | 2085 (9.1) | 0.300 (<0.001) |
Hyperlipidemia | 396 (8.0) | 686 (3.0) | 0.221 (<0.001) |
Obesity | 141 (2.8) | 202 (0.9) | 0.146 (<0.001) |
Diabetes | 727 (14.6) | 1125 (4.9) | 0.333 (<0.001) |
Thyroid disorders | 779 (15.7) | 1866 (8.1) | 0.235 (<0.001) |
Chronic renal disease | 1977 (39.8) | 3031 (13.2) | 0.633 (<0.001) |
Liver diseases | 33 (0.7) | 66 (0.3) | 0.055 (<0.001) |
Osteoporosis | 548 (11.0) | 2669 (11.6) | 0.018 (0.257) |
Paget’s disease of bone | 22 (0.4) | 28 (0.1) | 0.061 (<0.001) |
Major fractures other than hip fracture | 501 (10.1) | 2503 (10.9) | 0.026 (0.103) |
Connective tissue disease | 256 (5.2) | 781 (3.4) | 0.087 (<0.001) |
Osteoarthritis | 1221 (24.6) | 3719 (16.2) | 0.210 (<0.001) |
Depression | 532 (10.7) | 1324 (5.8) | 0.181 (<0.001) |
Dementia | 551 (11.1) | 2537 (11.0) | 0.002 (0.928) |
