Fig. 1: In silico identification of chromatin-binding proteins enriched at the promoters of G1/S and G2/M DREAM target genes.
From: HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexes
The TFEA.ChIP tool54 was utilized for screening the ReMap2022 database for chromatin-binding proteins enriched at the promoters of (a) G1/S (n = 109) or (b) G2/M (n = 132) DREAM target genes (Supplementary Data 3). TFEA.ChIP maps ChIP-Seq peaks onto regulatory regions defined by the GeneHancer database96 and associates these peaks with the genes regulated by those regions. The plots show Log2(Odds Ratio) versus Log10(adjusted p-value) as calculated by the TFEA.ChIP tool for each protein (represented as a single dot) in all included ChIP-Seq experiments.
