Table 2 Diagnostic accuracy (area under the curve, AUC) of hsCRP and lipidomic signatures in predicting pediatric inflammatory bowel disease compared to symptomatic controls in the validation cohort

From: Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

Evaluated models

AUC (95% CI)

P value vs hsCRP

hsCRP

0.73 (0.63–0.82)

reference

Full model (30 molecular lipid species)

0.85 (0.77–0.92)

0.001

LacCer(d18:1/16:0)

0.76 (0.67–0.84)

0.53

hsCRP + LacCer(d18:1/16:0)

0.79 (0.70–0.87)

0.09

PC(18:0p/22:6)

0.71 (0.61–0.81)

0.80

hsCRP + PC(18:0p/22:6)

0.76 (0.66–0.85)

<0.001

PC(18:0p/22:6) + LacCer(d18:1/16:0)

0.86 (0.78–0.92)

<0.001

hsCRP + LacCer(d18:1/16:0) + PC(18:0p/22:6)

0.86 (0.77–0.92)

<0.001

  1. AUC area under the curve, CI confidence interval, hsCRP high sensitivity C-reactive protein.
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