Table 3 Youden index, sensitivity, specificity, positive likelihood ratio (LR), and negative LR of hsCRP compared with two molecular lipids, LacCer(d18:1/16:0) and PC(18:0p/22:6), in predicting pediatric inflammatory bowel disease in the validation cohort

From: Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

Evaluated model

Youden index (J)

Sensitivity (%)

Specificity (%)

LR(+)

LR(-)

hsCRP

0.42

67.5

70.3

2.3

0.5

PC(18:0p/22:6) and LacCer(d18:1/16:0)

0.66

83.8

78.4

3.9

0.2

hsCRP

NA

90.0

35.1

1.4

0.3

PC(18:0p/22:6) and LacCer(d18:1/16:0)

NA

90.0

67.6

2.8

0.1

hsCRP

NA

29.4

90.0

3.2

0.8

PC(18:0p/22:6) and LacCer(d18:1/16:0)

NA

66.3

90.0

7.1

0.4

  1. The first two rows represent the diagnostic test statistics based on optimal Youden index. Rows three to six show statistics based on fixed sensitivity at 90% and a fixed specificity at 90%.
  2. hsCRP high sensitivity C-reactive protein, LR(+) likelihood ratio for positive test result, LR(–) likelihood ratio for a negative test result.
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