Fig. 3: Identification of immune cell populations in the lungs of LPS + PA14 and PA14 mice by scRNA-seq. | Nature Communications

Fig. 3: Identification of immune cell populations in the lungs of LPS + PA14 and PA14 mice by scRNA-seq.

From: Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure

Fig. 3

a UMAP embedding of the integrated expression profile of 46,826 cells from two conditions (LPS + PA14 and PA14), each comprised of three biological replicates. Distinct clusters are annotated and color-coded. b Expression of canonical markers used to annotate clusters, in conjunction with automated annotation using SingleR v2.2.0 (ImmGen reference scRNA-seq dataset). c Proportions of cell types represented in the two conditions, including the total count of cells in each cell type and the experimental condition. d Feature plot visualizing the expression of Aoah, the color of points (cells) represents the expression level of Aoah. Cell types are labeled, and the plot is split by experimental condition to highlight differences in expression levels between cells from LPS + PA14 and PA14 mice. n = 3 mice per group.

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