Table 1 Most impactful consequences of imperfect drive performance
From: Germline Cas9 promoters with improved performance for homing gene drive
Problem | Haplolethal modification | Haplosufficient modification | Female-fertility suppression |
|---|---|---|---|
Low drive conversion | Slower drive | Slower drive | Much lower power |
High germline resistance | Faster drive | Faster drive | Slower drive |
High embryo resistance | Possible failure | Slower drive | Lower powera |
High somatic expression | Fitness cost possible failure | Possible small fitness cost | Large fitness cost lower powera |
