Fig. 6: Model of the evolution and function of Pit1 and Pit2. | Nature Communications

Fig. 6: Model of the evolution and function of Pit1 and Pit2.

From: An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function

Fig. 6

The ancient Pit gene is a conserved resistance gene in Poaceae species and appears to have been duplicated in Oryza species. After duplication, Pit2 is under positive selection and the three important residues have evolved from LCG in Pit1 to PFW in Pit2, leading to Pit2 losing the ability to localize in the plasma membrane but gaining a new function to suppress Pit1-mediated cell death.

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