Fig. 8: Conditional loss of Ankrd11 in the neural crest causes dysregulated expression of a diverse set of genes at E11.5. Related to Supplemental Fig. 6.

a Dotplots showing statistically significantly differentially expressed genes (DEGs) between the Ankrd11^nchet and Ankrd11^ncko genotypes for each cluster. Dots are colored according to average log fold-change of expression from Ankrd11^nchet genotype (negative change indicates expression is lower in Ankrd11^ncko compared to Ankrd11^nchet, and a positive change indicates higher expression). The dot radius corresponds to the percent of cells in each cluster that express (i.e., show the presence of at least one transcript) the gene of interest. Genes displayed are ordered according to absolute average log2 fold-change (highest at the top, lowest at the bottom). b Heatmap plot showing scaled expression of differentially expressed genes between the Ankrd11^nchet and Ankrd11^ncko genotypes for each cluster. Cells are ordered according to their clustering. Genes displayed are ordered according to absolute average log2 fold-change (highest at the top, lowest at the bottom). c Violin plots showing scaled expression of selected differentially expressed genes between the Ankrd11^nchet and Ankrd11^ncko for each cluster. Genes were selected by taking the 8 highest absolute average log2 fold-change values from each marker group. n = 3 Ankrd11^nchet and n = 3 Ankrd11^ncko samples from at least 2 independent litters. Source data are provided as a Source Data file.