Fig. 1: HFD feeding in LDLr−/−.Leiden mice results in obesogenic phenotype.
From: Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD
a Body weight in chow-fed (white bars; n = 6) and HFD-fed (gray bars; n = 15) LDLr−/−.Leiden mice after 24 weeks (P = 0.025); b ALT levels (pooled plasma of 3 mice; n = 2 for chow; n = 2 for HFD; P = 0.002); c AST levels (pooled plasma of 3 mice; n = 2 for chow; n = 2 for HFD; P = 0.02); d Hepatic cholesterol ester concentration (n = 6 for chow; n = 14 for HFD; P < 0.0001); e Hepatic free cholesterol concentration (n = 6 for chow; n = 14 for HFD; P < 0.0001); f Hepatic triglyceride concentration (n = 6 for chow; n = 14 for HFD; P < 0.0001). Values are shown in box and whisker plots, data are median (horizontal line), interquartile range (boxes), and min. to max. (error bars); Data consist of biological replicates where HFD-fed mice are compared to control chow-fed mice. A two-sided Student’s t-test was used to test the statistical significance; *p < 0.01.
