Fig. 2: HFD feeding induces liver pathology associated to MASH.
From: Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD
a Macrovesicular steatosis in chow-fed (white bars; n = 6) and HFD-fed (gray bars; n = 14) LDLr−/−.Leiden mice after 24 weeks (P < 0.0001); b Number of inflammatory aggregates (n = 6 for chow; n = 14 for HFD; P = 0.01); c Perisinusoidal fibrosis area (n = 5 for chow; n = 14 for HFD; P = 0.02). Values are shown as floating bars (min. to max.), line indicates mean. Data consist of biological replicates where HFD-fed mice are compared to control chow-fed mice. A two-sided Student’s t-test with Welch’s correction was used to test the statistical significance; *p < 0.05.
