Fig. 6: Proposed model for SARS-CoV-2 replication organelles. | Nature Communications

Fig. 6: Proposed model for SARS-CoV-2 replication organelles.

From: Nanoscale cellular organization of viral RNA and proteins in SARS-CoV-2 replication organelles

Fig. 6

Replication organelles (ROs) comprise various RNA species (vgRNA, dsRNA) and proteins (RdRp, nsp3) organized by remodeled cellular ER membranes. Our data support a model which specifies the spatial organization of ROs at early (left panel) and late (right panel) stages of infection. Specific RNA and protein molecules are shown to be distinctly organized within the ROs. The replication and transcription of SARS-CoV-2 RNA occur within the double-membrane vesicles (DMVs) and vesicle packets (VPs) in proximity to RdRp.

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