Fig. 3: Blood stage parasite detection was delayed and reports of symptoms decreased in CHMI 3 and 4. | Nature Communications

Fig. 3: Blood stage parasite detection was delayed and reports of symptoms decreased in CHMI 3 and 4.

From: Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms

Fig. 3

A Parasitemia (p/ml) measured by quantitative PCR (qPCR) of Pf18s rRNA for each participant through the 4 CHMI (CHMI 1 n = 8, CHMI 2 n = 8, CHMI 3 n = 8, CHMI 4 n = 5)). Colored lines represent each participant. B Kaplan–Meier survival curve where each colored line indicates the percent of participants without patent parasitemia by blood smear on each CHMI. P value are based on the log-rank (Mantel–Cox) test comparing the time to first positive result between CHMI 1 and each other CHMI. C Blood stage multiplication was calculated for each participant (dots color coded as in (A)) for each CHMI using the increase in parasitemia over time from first qPCR detection until treatment. Data are presented as median and interquartile range. No significant differences were found between CHMI 1 and CHMI 2-4, Holm-Šídák’s multiple comparisons test. D The total number of symptom reports by each participant that completed all 4 CHMI is indicated by a line (n = 5). Statistical differences were tested using the Dunn’s multiple comparisons test comparing each CHMI to CHMI 1 and all P values are two-sided. Source data are provided as a Source Data file.

Back to article page