Fig. 7: Working model of RNF214 functions in HCC. | Nature Communications

Fig. 7: Working model of RNF214 functions in HCC.

From: The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation

Fig. 7

YAP and TAZ are transcription co-activators that activate transcriptional activities of TEADs to promote HCC tumorigenesis. RNF214 induces TEADs non-proteolytic ubiquitylation at a single conserved lysine site, enhances the interactions between TEADs and YAP, and then promotes transactivation of the downstream genes, thereby leading to enhanced tumor progression. The figure created with BioRender. com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license (https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en).

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