Fig. 3: TB vaccination induces distinct clusters of CD4+ T cells. | Nature Communications

Fig. 3: TB vaccination induces distinct clusters of CD4+ T cells.

From: Adolescent BCG revaccination induces a phenotypic shift in CD4+ T cell responses to Mycobacterium tuberculosis

Fig. 3

a Unsupervised WNN clustering and UMAP projection of 42,067 CD4+CD69+CD154+ T cells measured by CITE-Seq reveals 11 distinct clusters. b Graph showing select genes used in cluster annotation. The percentage of cells expressing select genes (size of circle) and the average expression of each gene (color of circle) by cluster is shown for the CD4+CD69+CD154+ T cells measured by CITE-Seq. c Ridge plot of the normalized antibody-derived tagged (ADT) surface marker expression on the CD4+ T cells by cluster. d Heatmap showing average gene expression per participant of the top 10 genes that distinguish the different clusters from each other.

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