Fig. 2: Mean change in 6-min walk distance by study group assignment.

Figure A depicts the 6-month change in 6-min walk (primary outcome) results for N = 90 participants. Mixed models for repeated measures (MMRM) were used to compare 6-month change in 6-min walk distance between the NR + resveratrol and placebo groups and between the NR alone and placebo groups using baseline, 3-month, and 6-month values for 6-min walk distance, adjusting for age, sex, race, and baseline 6-min walk. The a priori statistical analysis plan defined a one-sided P value of <0.10 to define statistical significance. The circle represents NR alone, the square represents NR + resveratrol, and the triangle represents placebo. Figure B depicts 3-month change in 6-min walk (secondary outcome) for N = 90 participants. Mixed models for repeated measures (MMRM) were used to compare change in 6-min walk distance between the NR + resveratrol and placebo groups and between the NR alone and placebo groups using baseline, 3-month, and 6-month values for 6-min walk distance, adjusting for age, sex, race, and baseline 6-min walk. The a priori statistical analysis plan defined a one-sided P value of <0.10 to define statistical significance. The circle represents NR alone, the square represents NR + resveratrol, and the triangle represents placebo. Figure C depicts 6-month change in 6-min walk among the 60 participants who took at least 75% of study pills. Mixed models for repeated measures (MMRM) were used to compare 6-month change in 6-min walk distance between the NR + resveratrol and placebo groups and between the NR alone and placebo groups using baseline, 3-month, and 6-month values for 6-min walk distance, adjusting for age, sex, race, and baseline 6-min walk. The a priori statistical analysis plan defined a one-sided P value of <0.10 to define statistical significance. The circle represents NR alone, the square represents NR + resveratrol, and the triangle represents placebo.