Fig. 4: Collateral sensitivity induced by β-lactamases is conserved across phylogenetically distant E. coli strains.
From: β-lactamase expression induces collateral sensitivity in Escherichia coli
a Phylogenetic tree depicting the relationships of 1573 representative E. coli genomes and highlighting the strains used in this study. Colours at the tip of tree branches represent different phylogroups, as indicated in the legend. b Collateral sensitivity response to azithromycin (AZI) and colistin (COL) associated with the presence of active β-lactamases in E. coli. Relative MIC (in log2 fold-change) was determined as the MIC of the β-lactamase-carrying E. coli relative to the β-lactamase-free strain carrying the empty vector. Black points represent the median values of six biological replicates, shown as individual blue points. The horizontal line represents no change in MIC relative to the control strain. Asterisks denote a significant decrease in MIC (*p < 0.05, **p < 0.01; two-sided Mann-Whitney U test). The data points have been slightly jittered to avoid overlapping. Source data are provided in Source Data file.
