Fig. 1: Schematic illustration of HBO-enhanced intratumoral delivery of engineered bacteria for photothermal immunotherapy. | Nature Communications

Fig. 1: Schematic illustration of HBO-enhanced intratumoral delivery of engineered bacteria for photothermal immunotherapy.

From: Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy

Fig. 1

a Scheme showing the preparation of photothermal fluorophores (cypate)-modified bacteria and the procedures for tumor therapy. b Scheme showing the engineered bacteria (EcN-cypate)-mediated PTT and HBO (and anti-PD-1)-enhanced systemic immune responses for tumor eradication. ECM, extracellular matrix; Treg, regulatory T cell; DC, dendritic cell; MDSC, myeloid-derived suppressor cell; M2, M2-type macrophage; M1, M1-type macrophage; PD-1, programmed death-1. a, b were created with BioRender.com (publishing license: MC26QF09XE).

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