Fig. 2: HBO-induced ECM depletion. | Nature Communications

Fig. 2: HBO-induced ECM depletion.

From: Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy

Fig. 2

a Schematic illustration of HBO-enhanced ECM depletion and intratumoral accumulation of bacteria. a was created with BioRender.com (publishing license: HO26QF3LQP). b–e Transcriptomic analysis results of the tumors from the 4T1 tumor-bearing mice with different treatments. b Volcano plot of all DEGs between the HBO-treated group (HBO+) and the control group (HBO–). c Heat map of the selected DEGs between the “HBO+” group and the “HBO–” group. Red and blue colors indicate the up-regulation and down-regulation, respectively. d Histogram presenting the GO enrichment analysis results of some selected DEGs between the “HBO+” group and the “HBO–” group. CC cellular component, MF molecular function, and BP biological process. e Dot plot illustrating the KEGG enrichment analysis results of some selected DEGs between the “HBO+” group and the “HBO–” group. Statistical significance in b, d, and e was calculated via two-tailed Student’s t test. n = 3 mice. Representative f immunofluorescence images of fibronectin and g Masson’s trichrome staining results (which can reflect the collagen contents) in the tumor slices from the mice with different treatments as indicated. The fibronectin and Masson’s trichrome staining were repeated for three times independently with similar results.

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