Fig. 5: Association between pointwise medial temporal lobe (MTL) thickness and contralateral, semi-quantitative neuropathology measures.

The t-statistic maps show the correlation between cortical thickness and the semi-quantitative neuropathology ratings based on tissue samples obtained from the MTL contralateral to the thickness measures (n = 47). Each row specifies the variable of interest with the covariates used in the analysis in parentheses. The first two rows show the association between thickness and tau burden, with and without correction for co-pathologies. Rows 3 and 4 show the patterns of correlation obtained between pointwise thickness and TDP-43 and α-synuclein pathology respectively. Clusters were defined based on an empirical threshold (uncorrected p < 0.01) and permutation testing with the Freedman & Lane method (1000 iterations) was used to assign each potential cluster a one-sided, corrected p-value. To account for multiple comparisons, the analysis uses cluster-level family-wise error rate correction. The clusters outlined in black indicate regions where a significant correlation was observed after correction for multiple hypothesis testing (corrected p < 0.05). No covariates were included in this model. (S subiculum, PrS-PaS: Pre/Parasubiculum, SRLM stratum radiatum lacunosum molecular, PP: perforant pathway, CA cornu ammonis, DG dentate gyrus, ERC entorhinal cortex, BA Brodmann area).