Fig. 4: T cell depletion increases viral loads and tumor burden of KSHV/EBV co-infected mice.

A Experimental outline of KSHV EBV co-infections with or without T cell depletion by i.p. injection of αCD8 (OKT8) and αCD4 (OKT4) antibodies. B Percentage of CD45⁺ CD3⁺, CD45⁺ CD4⁺, CD45⁺ CD8⁺ T cells in blood throughout the course of the experiment comparing mice with and without T cell depletion. Data present mean and SD. Two way mixed effects model with Geisser-Greenhouse correction, for comparisons Bonferroni’s multiple comparison test was performed. Significant p-values left to right: CD3: 0.0006; < 0.0001; < 0.0001; < 0.0001. CD4: 0.0007; < 0.000; < 0.0001; 0.0002; CD8: 0.0024; 0.0002; < 0.0001; 0.0129. C EBV copies/ml blood and (D) KSHV copies/ml blood displayed as area under the curve (AUC) during the experiment for KSHV/EBV co-infected mice with and without T cell depletion. Mean with SD, two sided MWU; Exact p-values are (C) 0.0086 and (D) 0.0252 (E) Tumor load of mock and KSHV/EBV co-infected animals with and without T cell depletion. Two sided MWU. Exact p values mock – non depl 0.0022; mock – depleted 0.0028. Composite data of 3 independent experiments (2 NSG-A2, 1 NSG) with N = 25 (non-depleted) and N = 13 (depleted) mice in (B) and N = 13 (non-depleted) and N = 9 (depleted) mice in (C, D). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Source data are provided as a Source data file.