Fig. 10: Chronic impact of galactic cosmic radiation (GCR) on kidney health. | Nature Communications

Fig. 10: Chronic impact of galactic cosmic radiation (GCR) on kidney health.

From: Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Fig. 10

a Representative images of haematoxylin and eosin (H&E), Masson’s trichrome, Martius scarlet blue (MSB), Periodic acid–Schiff (PAS), Picrosirius red, and Von Kossa stained kidney sections from NSRL22A GCRsim-exposed mice (~ 2.5-year dose-equivalent) harvested ~ 6 months post-exposure. Arrows indicate microthrombi in the glomerular capillary tufts visible in H&E, Masson, MSB and PAS stains. Scale bar: 50 µm (left panel) and 100 µm (right). b Urine (Protein:Cr, Glucose:Cr, Magnesium:Cr, FENa, FECa, FEMg(Corr), FEPO4) and plasma (sodium, chloride) physiological measurements from NSRL22A GCRsim-exposed mice ( ~ 2.5-year dose-equivalent) harvested ~ 6 months post-exposure that were normalised to sham controls for illustrative purposes. Boxed P-values report the two-way ANOVA treatment group factor result. Data are mean ± SD. A P-value of < 0.05 was considered significant. Cr Creatinine, FE Fraction Excretion, Corr corrected for albumin, Ca calcium, Na sodium, Mg magnesium, PO4 phosphate, N = 12 biologically independent animals per sex per group. ‘Source data are provided as a Source Data file.

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