Fig. 6: Biomolecular evidence for spaceflight-induced nephron remodelling.
a A curated list of multi-omic over-representation analysis of GO—biological process ontological terms related to remodelling. b A curated list of multi-omic over-representation analysis of KEGG pathway ontological terms related to remodelling. a, b To integrate datasets from different omics modalities, species, missions and tissues, all biomolecules (e.g. phosphopeptides, proteins, transcripts and methylated DNA) were converted to the human orthologs where necessary and linked back to their HGNC gene symbol, aggregated and collapsed to single genes (e.g. multiple phosphosites, isoforms, CpG sites). An unadjusted, two-tailed -Log10(P-value) of 2 was considered significant for ontological term enrichment. Enrichment ratio; the number of differentially regulated hits in a dataset that belong to a given ontological term, normalised to the total number of statistically significant hits in the respective dataset. c STRING protein-protein interaction network of previously absent inflammation-associated and collagen I-associated ECM proteins that appeared in cosmonauts’ urine (n = 10) after 166–199 days of spaceflight exposure.
