Fig. 4: Liver endothelial cell heterogeneity and inferred zonation after PVE.
From: Cell atlas of the regenerating human liver after portal vein embolization
a Schematic illustrates diversity of endothelial cells along the portal-central axis within a liver lobule. UMAP plots representing combined ECs from all medical conditions are colored by condition (b) or annotated subpopulation (c) (EC endothelial cells, LSECs liver sinusoidal endothelial cells, fenestr. fenestrated, MT mitochondrial). d Violin plots show distribution of normalized marker gene expression for endothelial cells subpopulations. e Proportion of each endothelial subpopulation across conditions (healthy, left; regenerating, middle; embolized, right). f Histogram shows comparison of LSECs (periportal, midzonal, and pericentral LSECs) pseudozonation across conditions. LSECs from regenerating and embolized conditions were projected onto a reference healthy zonation trajectory. g Distribution of each LSEC subpopulation from healthy, regenerating and embolized condition is shown along the pseudozonation trajectory. Source data are provided as a Source Data file for (b, c–g).
