Fig. 3: [3H]OXD-2314 autoradiographic binding in human post-mortem brain tissues of tauopathies. | Nature Communications

Fig. 3: [3H]OXD-2314 autoradiographic binding in human post-mortem brain tissues of tauopathies.

From: Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

Fig. 3

A Autoradiographic detection of [3H]OXD-2314 binding in post-mortem cortical or hippocampal brain tissue samples from healthy control (HC), Alzheimer’s disease (AD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) cases. Top row shows total [3H]OXD-2314 (3 nM) binding and bottom row shows non-specific binding of [3H]OXD-2314 (3 nM) with displacement by unlabeled OXD-2314 (3–10 μM) in adjacent sections. Representative data of 2–3 cases per diagnosis. B High-resolution autoradiography image of [3H]OXD-2314 (3 nM, black) in CBD cortical tissue. [3H]OXD-2314 signal is overlaid with immunohistochemical (AT8) staining to indicate phospho-tau (turquoise) distribution. Scale bar, 20 µm.

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