Fig. 6: PET imaging and radiometabolite analysis of [18F]OXD-2314 in baboon.
From: Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies
A Time-activity curves of standardized uptake values (SUV) in male (solids, n = 1) and female (open, n = 1) baboon whole brain (circles), cortex (triangles), and cerebellum (squares) from baseline PET scans using [18F]OXD-2314 over 0-90 min. B Radiometabolite analysis from male (n = 1) and female (n = 1) baboon venous blood taken during baseline PET scans using [18F]OXD-2314. The fraction of unchanged [18F]OXD-2314 in plasma was measured by high-performance liquid chromatography at six-time points between 2 and 90 min post-injection.
